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Bulimia nervosa, also known is bulimia. Bulimia word is comes from the Latin (bulimi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

a) from the Greek. It is eating disorder. Bulimia is a serious, potentially life-thre

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

tening condition. Because it's so intimately entwined with self-image — it's not just

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

about food — bulimia can be difficult to overcome. Person with bulimia eats a lot of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ood in a short amount of time (binges) and then tries to prevent weight gain by getti

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

g rid of the food, called purging. This purging is done in order to compensate for th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e excessive intake of the food and to prevent weight gain. Purging typically takes th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

form of vomiting; inappropriate use of laxatives, enemas, diuretics or other medicat

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

on; and excessive physical exercise.

Bulimics are also susceptible to other compulsi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ns, affective disorders, or addictions. Bulimia is often less about food, and more to

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

do with deep psychological issues.About 6% of teen girls and 5% of college-aged femal

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

es are believed to suffer from bulimia. Approximately 10% of identified bulimic patie

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ts are men. Binge/purge episodes can be severe, sometimes involving rapid and out of

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

control feeding that can stop when the sufferers "are interrupted by another person"

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r when their stomach hurts from over-extension. This cycle may be repeated several ti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

es a week or, in serious cases, several times a day. Unlike anorexics, bulimics expe

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rience significant weight fluctuations, but their weight loss is usually not as sever

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

or obvious as anorexics.

Causes of Bulimia Nervosa

1.Genetic contribution.

2.Eati

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

g disorders ( anorexia and bulimia).

3.Certain neurological or medical conditions.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

.Depression.

5.Anxity.

6.Harmones imbalances (Testosterone and low estrogen levels)

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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