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Article Dump - Common Causes of Deafness and How You May Be Able to Prevent It
Deafness can vary from mild to severe. Deafness at birth is called congenital deafness and that which occurs after birth is called adventitious deafness. The causes of adve
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
ntitious deafness are many. Lifestyle has a vital responsibility for cause of hearing loss and one of the main causes of adventitious deafness is noise. Some common causes
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
of deafness are:
• Hereditary Disorders: Hereditary deafness happens when the parents pass the defect on to their children. It means that people are born
• Hereditary Disorders: Hereditary deafness happens when the parents pass the defect on to their children. It means that people are born
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
deaf and this is generally caused by the malformations of the inner ear.
• Genetic Disorders: Genetic deafness occurs when the baby is in the mother's wo
• Genetic Disorders: Genetic deafness occurs when the baby is in the mother's wo
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
b.
• Prenatal Exposure to Disease: When pregnant mothers suffer from rubella, influenza or mumps, the baby born will either be deaf or will have some hear
• Prenatal Exposure to Disease: When pregnant mothers suffer from rubella, influenza or mumps, the baby born will either be deaf or will have some hear
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ing problem.
• Noise: Loud noise like gunshots, firecrackers, explosions and rock concerts tends to damage the ear mechanisms. A single exposure to loud n
• Noise: Loud noise like gunshots, firecrackers, explosions and rock concerts tends to damage the ear mechanisms. A single exposure to loud n
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
ise does not damage the eardrum. Repeated exposure to sound over a long period of time will affect the ear with moderate to severe hearing loss.
• Disease:
• Disease:
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
> There are certain diseases that cause loss of hearing such as meningitis, mumps, chicken pox and cytomegalovirus. In the case of meningitis, the inner ear tends to become
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
inflamed which leads to deafness.
• Trauma: A hole in the eardrum, a fractured skull or changes in air pressure lead to deafness.
• Wax:
• Trauma: A hole in the eardrum, a fractured skull or changes in air pressure lead to deafness.
• Wax:
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
> The ear canal produces a waxy substance, which is useful in lubricating and protecting the tissues. This has to be cleaned out once in a while. If not done, the wax will
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
uild leading to short term deafness. Even foreign substances such as the tip of a cotton bud or a hairpin can cause hearing loss if they puncture the eardrum. This is not t
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
o serious as the eardrum heals on its own, although it can take a few weeks.
• Excess Mucus: Excess mucus is caused either due to the common cold, hay fev
• Excess Mucus: Excess mucus is caused either due to the common cold, hay fev
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
er or other allergies. This blocks the Eustachian tube, which leads to loss of hearing.
• Ear Infections: During an ear infection, the fluid and pus fill
• Ear Infections: During an ear infection, the fluid and pus fill
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
in the middle ear. This does not allow full transmission of sound and leads to partial hearing.
• Drugs: There are certain drugs like c
• Drugs: There are certain drugs like c
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
hloroquine, which lead to temporary deafness.
• Age-related Hearing Loss: This type of hearing loss is commonly found in old people. This is normal and ra
• Age-related Hearing Loss: This type of hearing loss is commonly found in old people. This is normal and ra
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
ely leads to deafness. Age-related hearing loss also known as 'presbycusis' begins with loss of certain speech sounds like 'S', 'F' and 'T'.
• Tinnitus: T
• Tinnitus: T
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
innitus is the ringing sound in the ears. Middle ear infection and damage caused by loud noises can cause tinnitus. This disease can cause psychiatric symptoms.
•
•
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
ccupational Hearing Loss: Men working in bars, pubs, and nightclubs are liable to have their sense of hearing impaired. Such people are exposed to loud noise most
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
of the time. The deafness is caused by the damage to the hair cells of the organ of Corti in the cochlea.
In addition to the above causes of deafness, there are many unkno
In addition to the above causes of deafness, there are many unkno
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
n causes. Loss of hearing is a serious problem. Some say it is worse than losing one's sight. People lose their quality of life due to the isolating nature of the condition
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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