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Cirrhosis of the Liver

A degenerative inflammatory disease that results in the hardening and scarring of liver cells. The liver becomes unable to function properly due to the scarred tissue which prevents the normal passage of

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

blood through the liver. Most common cause is excessive alcohol consumption. Malnutrition and chronic inflammation can also lead to liver malfunction. Those in the later stages may develop anemia, bruising due to bleeding under

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he skin, and edema. The liver is the body's principal organ of detoxification... As long as the liver function is intact, the blood stream remains pure. When it becomes impaired, the toxins enter the circulation and cause

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

irritation, destruction, and eventually death. -Dr. Henry G. Bieler, M.D. The liver detoxifies metabolic wastes, ammonia ( a by-product from too much protein intake), insecticide/pesticide residues, drugs, alcohol, and t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ousands of other toxins, poisons, and heavy metals.

Symptoms:

Constipation or diarrhea, upset stomach, fatigue, weakness, poor appetite, weight loss, enlarged liver, vomiting, red palms, and jaundice.

Recommendations:

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

i>B vitamins, especially Vitamin B1 (Thiamine)- Vitamin B1 has been shown to significantly reduce blood glucose levels in patients with liver cirrhosis and restore levels of thiamine pyrophosphate, an essential co-factor in inte

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

mediary metabolism, to normal levels in chronic liver disease patients. -Scandinavian Journal of Gastroenterology, 13(2), 1978, p. 133-138 AND Journal of Gastroenterology Hepatology, 6(1), January-February 1991, p.59-60. We sugg

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

est a high quality whole food supplement, like VITAFORCE™ that is complete and made from whole foods. Make sure you know what you are getting from the nutritional label. Also, eat brown rice, legumes, peas, kelp, dulse, plums,

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

spirulina, raisins, broccoli, asparagus, and most nuts.

Vitamin A deficiency has also been linked to liver disease. In one study, it was found that 9 out of 11 patients with cirrhosis of the liver were Vitamin A defici

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ent. When they began supplementation, 7 of those 9 patients experienced significant improvements. Hepatology, (4), July-August 1981, p. 348-351. We suggest a high quality whole food supplement, like VITAFORCE™ that is complete

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nd made from whole foods. Make sure you know what you are getting from the nutritional label.

Eat a well balanced diet of 75% or more raw foods and fresh "live" (just squeezed) juices. This will give the body highly

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

utritious and easily absorbable whole foods which gives much more energy and builds immunity.

Take organic, unfiltered flax seed oil and primrose oil. There is typically an imbalance of essential fatty acids found in t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

hose of with Cirrhosis of the Liver.

Consume at least 8 glasses of distilled water throughout the day (not at meals) to help flush out toxins.

Get plenty of rest and do not over-exert yourself.

Herb

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

l detoxification products may be helpful in cleansing the liver of poisons and heavy metals. We suggest using formulas that use organic, whole herbs. If interested, tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

dder-Cleanse_p_267-138.html" target="_blank">Click Here to the Liver and Gallbladder Cleanse Program

Get at least 15-30 minutes of fresh air and sunshine (if possible) a day. This

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ill help to re-invigorate you.

Click here to try VITAFORCE™

Things to Avoid:

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Do NOT eat any animal foods (meat, fish/dairy, eggs).

Do not take any drugs except those prescribed by your doctor. Drugs cause severe damage to the liver, because it has to keep these poisons from entering the blo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

d stream.

Do not consume alcohol in any form.

References:

1) James F. Balch, M.D, Phyllis A. Balch, C.N.C, "Prescription for Nutritional Healing," (1997)

2) R. Hassan, et al. "Effect of Thiamine on Glucose

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Utilization in Hepatic Cirrhosis," Journal of GAstroenterology Hepatology, 6(1), January-February 1991, p.59-60

3) J.E. Rossouw, et a;., "Red Blood Cell Transketolase Activity and the Effect of Thiamine Supplementation in Pati

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nts with Chronic Liver Disease," Scandinavian Journal of Gastroenterology, 13(2), 1978, p. 133-138

4) H.F. Herlong, et al., "Vitamin A and Zinc Therapy in Primary Biliary Cirrhosis," Hepatology, (4), July-August 1981, p. 348-35

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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