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    Only somebody who has lived with anxiety – as either a sufferer or a carer – knows how devastating it can be. The aff
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ect can be seen and felt across every aspect of your life for years and years.

    So how does anxiety make you withdraw
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    from life?

    Basically, people with anxiety live their lives defensively, at a level where they are merely ‘coping’ i
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    nstead of ‘embracing’. They are life’s ‘passengers’, passive in their emotional and physical relationship with the wo
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    rld around them - rather than ‘activists’ who engage with their surroundings and interact with people.

    Now I want to
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    share something with you that will probably – hopefully! – shock you.

    Have you ever sat down with pen and paper and
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    worked out how much time you spend feeling anxious every day of your life? An hour? Two? Four? Ten?!

    If you spend ev
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    en a single hour a day in anxious mode, that equates to 30 hours a month – that’s two ‘waking’ days every month where
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    you could be playing with the kids, training for a marathon run, taking up a hobby, visiting old friends… LIVING you
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    r life. Instead, you’re wasting that valuable time on your anxiety.

    At it’s worst, I know my anxiety had reached the
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    point where it took over 90% of my waking thoughts. It left me totally exhausted.

    Looking back, I now know that by a
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    llowing this anxiety to have such a huge stake in my life took real commitment on my behalf!

    So, I took control and
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    by doing so, I was rewarded with all this extra time… and all this additional energy with which to fill the hours in
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    a positive way! What a bonus!

    I cannot tell you the sense of relief and liberation this sparked in me. And the most
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    wonderful thing is, just as anxiety is a downward spiral that sees you withdraw from life, so this liberation is an
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    plifting cycle which grows and grows. Once you begin, you can’t contain it!

    I know that if I hadn't taken control an
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    d eliminated my anxiety for good, I’d still be on that downward spiral… getting ever more sucked into the anxiety aby
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ss where your every waking moment is dominated by fear.

    So, don’t be afraid of the fear, the unknown. Instead, look
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    forward to all the wonderful possibilities that YOUR life has yet to put your way!

    Looking at my family, I’m so glad
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    I faced up to my own fear. The answer is never in retreating from life… it’s everything to do with defeating anxiety


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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