Article Dump - Health and Fitness

The mouth is the gateway to the body... good health begins with good teeth. Tooth decay, infection and/or gum disease can lead to a variety of ailments and just generally '

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

feeling bad.' Here's a list of Do's and Don'ts for keeping your oral hygiene the best it can be:

Oral Hygiene Do's

Visit your dentist regularly f

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r check-ups and cleaning.

Visit an orthodontist for an evaluation if you see any of the early warning signs of orthodontic problems.

Have your child(r

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n) evaluated by an orthodontist by age seven. Many orthodontic problems can be more easily corrected before tooth and facial growth is complete.

Brush your teeth

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

at least twice a day using a soft-bristled toothbrush and a fluoride toothpaste.

Floss between your teeth at least once a day, after dinner and before bedtime. (

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Tip: Use toothpaste on your floss for extra fresh breath.)

Rinse and gargle with the mouthwash, ideally right before bedtime.

Eat a balanced diet, limi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

between-meal snacks and eliminate sugary foods.

Clean your tongue when your brush your teeth. (Tip: Instead of using toothpaste to brush your tongue, dip your t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

othbrush in mouthwash.)

Drink plenty of liquids, especially water to keep your mouth moist. (Tip: If your mouth is dry, try sucking in your cheeks as if eating so

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ething sour to increase flow from the salivary glands.)

Oral Hygiene Don'ts

Don't forget to clean behind your back teeth.
Do

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

n't give mouthwash or fluoride toothpaste to young children, as they can swallow it.

Don't clean your tongue so hard that it hurts.

Don't rely on mout

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

wash alone too keep your teeth and gums clean and your breath fresh. Practice complete oral hygiene.

Don't ignore your gums - you can lose your teeth as well as

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ave bad breath.

Don't drink too much coffee.

Don't smoke.

For those wearing braces or other orthodontic appliances, keeping teeth and gums

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

lean may be a bit more difficult, but the resulting smile will be worth the effort. If you wear braces...

Braces Do's

Brush after every meal. If

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

you can't brush right away, rinse your mouth (and removable appliance) with water.

Floss every day. Your orthodontist can give you a floss threader if you're hav

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ng difficulties.

Chew only sugarless gum.

Call your orthodontist if anything is loose or broken.

Braces Don'ts
t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
ong>

Don't miss your orthodontic appointments. Missed or delayed appointments mean you'll have to wear your braces longer.
Don't eat hard, sticky or che
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
y foods, crunchy foods.
Don't chew on pens, pencils, ice, fingernails or anything that might break your braces.

Shiny clean teeth and fresh breath are
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
good reasons for practicing good oral hygiene, but the most important reason is that keeping your gums and teeth clean and healthy will help you keep your teeth throughout
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
your life. Although some diseases and conditions can make dental disease and tooth loss more likely, most of us have a great deal of control over whether we keep our teeth
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
nto old age. Wouldn't you rather be chewing with your own natural teeth?

Avis Ward of AWard Consulting, LLC

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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